Neurology Clinical Programs
Multiple Sclerosis
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Research Opportunites

The UCSF MS Center is an internationally recognized leader in multiple sclerosis clinical research. Under the direction of Dr. Bruce Cree and his colleagues, the Research Center conducts clinical trials involving the use of experimental treatments, as well as observational studies that help better understand the natural history of the disease. We are trying to understand what role genes, the environment and the immune system have in multiple sclerosis and other neuroimmunological diseases. Although our primary clinical research focus is on MS, we also study other diseases such as neuromyelitis optica (NMO), optic neuritis, transverse myelitis, encephalitis and sarcoidosis.

Clinical research studies include only individuals who choose to participate in them. If you are interested in research conducted at our Center, please inform your neurologist or nurse. If you are currently a patient of the UCSF MS Center, some of these studies may be completed during your clinic visits. Some research studies are open for enrollment even if you do not receive your neurological care at UCSF.

Should you be interested in a research study, you can be given an unsigned copy of the study consent form to think about and discuss with anyone before making your decision about entering the study. Please take your time to decide whether you would like to participate, and ask the study doctor or study staff to explain any words or information in the consent form that you do not clearly understand.

Our research is being conducted at the UCSF Neurosciences Clinical Research Unit located on the first floor in Suite 130 at the Sandler Neurosciences Center, 675 Nelson Rising Lane in San Francisco. (downloadable map).

The UCSF MS Research Center is conducting the following experimental studies (downloadable version):

Clinical Trials of Disease Modifying Treatments

Open to enrollment for patients with relapsing multiple sclerosis

    Vitamin D - RCT Study- A randomized controlled trial of vitamin D in multiple sclerosis
    ReBUILD- A randomized trial to assess an identified molecule as a remyelinating agent in Multiple Sclerosis
    RADIANCE STUDY-A randomized study to evaluate the efficacy and safety of RPC1063

Open to enrollment for patients with secondary progressive multiple sclerosis

Open to enrollment for patients with relapsing or secondary progressive multiple sclerosis

Observational Studies

Open to enrollment for MS patients

    EPIC Study
    Visual Evoked Poternials (VEP) in the evaluation of Neurological Disease
    Neuroimmunology Banking Studies- The collection and banking of samples for studies to understand molecular and cellular immunological mechanisms in MS.
    Genetic Susceptibility to Develop MS

Open to enrollment for patients with neuromyelitis optica or neurosarcoidosis

    Neuromyelitis Optica-T Cell Recognition of CNS Autoantigens in Multiple Sclerosis and Neuromyelitis Optica
    Neuroimmunology Banking Studies- The collection and banking of samples for studies to understand mechanisms of B cell immunology in NMO.
    Sarcoid-Neurological Manifestations of Sarcoidosis and Ways to Distinguish Sarcoidosis from other Causes of Nervous System Inflammation

Ongoing studies that are closed to enrollment

    OPERA - Study To Evaluate The Efficacy And Safety Of Ocrelizumab In Comparison To Interferon Beta-1a (Rebif®) In Patients With Relapsing Multiple Sclerosis
    ORATORIO - Study to evaluate the efficacy and safety of ocrelizumab in adults with Primary Progressive Multiple Sclerosis.
    PREFERMSStudy- A randomized, Open-label Study to Evaluate the Patient Retention of Fingolimod.
    Riluzole - Study to see if riluzole is safe and effective in treating patients with early Multiple Sclerosis (MS) and Clinically Isolated Syndrome (CIS).
    STRATIFY - To better understand whether antibodies to JCV may be used to predict whether a patient is at higher or lower risk for developing PML.
    Vitamin D - Pilot Study - Pharmacodynamic and immunologic effects of Vitamin D supplementation in patients with multiple sclerosis and healthy controls.