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Neurology Clinical Programs
Multiple Sclerosis
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Our Laboratories

Many of our providers are principal investigators (PI's) engaged in laboratory research. The following are links to more information about their programs.

The von Budingen Laboratory

The von B├╝dingen Lab is part of the Multiple Sclerosis and Neuroimmunology Research Group at UCSF. We study how B cells are involved in autoimmune disorders of the brain and spinal cord.

Our goal is to use newly gained knowledge for translation into therapies and disease markers. Please visit our lab website by clicking here.

The Zamvil Laboratory

The focus of our research is to investigate the mechanisms involved in the regulation of antigen presentation and T cell activation in the central nervous system (CNS) autoimmune disease model, experimental autoimmune encephalomyelitis (EAE).

Our goal is to apply this knowledge to the development of new treatments for multiple sclerosis (MS). Molecular, cellular, and both in vivo transgenic and knock-out approaches are utilized in our work. Please visit our lab website by clicking here.

Multiple Sclerosis Research Group/Molecular Neuroimmunology Laboratory

The principal aim of our laboratory is to identify the major genetic factors that predispose to autoimmunity and tissue injury in the central nervous system. Our goals are to apply and integrate novel molecular, immunological, informatic, statistical, and epidemiological experimental approaches, and translate this information into better diagnosis, prognosis, treatment and prevention of multiple sclerosis and other neuroinflammatory diseases. Please visit our lab website by clicking here.

Neuronal/Glial Interactions that Control Myelination

Jonah Chan, PhD is principal investigator whose lab is working to understand the fundamental glial/neuronal interactions and the molecular mechanisms that regulate myelination. Please visit our lab website by clicking here.

Neurogenesis and Oligodentritics Biology

Sam Pleasure, MD, PhD in principal investigator whose lab is studying patterning, morphogenesis, migration and connectivity in the developing brain using genetic and in vitro manipulation. Please visit our lab website by clicking here.