Studies and Trials


The UCSF MS Research Center is conducting the following experimental studies:

Clinical Trials of Disease Modifying Treatments


Open to enrollment for patients with multiple sclerosis
    TRIUMPHANT Study - Treatment of fatigue with methylphenidate, modafinil and amantadine in multiple sclerosis

Open to enrollment for patients with relapsing multiple sclerosis
    Vitamin D - RCT Study - A randomized controlled trial of vitamin D in multiple sclerosis

Open to enrollment for patients with progressive multiple sclerosis
    NAC Pilot Study - A randomized study to evaluate the efficacy of N-acetyl cysteine on fatigue in patients with progressive multiple sclerosis

Open to enrollment for patients with optic neuritis
    ReCOVER - A randomized controlled trial of Clemastine Fumarate as a remyelinating agent in acute optic neuritis

Open to enrollment for patients with neuromyelitis optica and neuromyelitis optica spectrum disorders
    MEDI-551 Study - A double-masked, placebo-controlled study with open label period to evaluate MEDI-551 in neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorders (NMOSD)

Interventional Trials


    IQooL My MS - Improving Quality of Life in Menopausal women with Multiple Sclerosis

Observational Studies


Open to enrollment for patients with multiple sclerosis
    EPIC Study - Understanding the long-term evolution of MS
    ORIGINS Study - Discovering the "triggers" of MS
    iMSMS - Microbiome research in MS
    Digital Cognition Study - Brain re-training in MS
    Neuroimmunology Banking Studies - The collection and banking of samples for studies to understand molecular and cellular immunological mechanisms in MS
    Genetic Susceptibility to Develop MS

Open to enrollment for patients with neuromyelitis optica or neurosarcoidosis
    Neuromyelitis Optica - T Cell Recognition of CNS Autoantigens in Multiple Sclerosis and Neuromyelitis Optica
    Neuroimmunology Banking Studies - The collection and banking of samples for studies to understand mechanisms of B cell immunology in NMO

Ongoing studies that are closed to enrollment

    CHORD Study - An open-label study to evaluate the efficacy and safety of Ocrelizumab in patients with relapsing remitting multiple sclerosis (MS) who had suboptimal response to other MS treatment
    Daybreak Study - An open-label extension study to evaluate the efficacy and safety of RPC1063 (ozanimod)
    OPERA - Study to evaluate the efficacy and safety of Ocrelizumab in comparison to Interferon Beta-1a (Rebif®) in patients with Relapsing Multiple Sclerosis
    ORATORIO - Study to evaluate the efficacy and safety of Ocrelizumab in adults with Primary Progressive Multiple Sclerosis.
    Sarcoid - Neurological manifestations of Sarcoidosis and ways to distinguish Sarcoidosis from other causes of nervous system Inflammation