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Vitamin D

Vitamin D - RCT Study- A randomized controlled trial of vitamin D in multiple sclerosis

This research is being done to see if giving a high dose of vitamin D to people with multiple sclerosis (MS) makes the disease better. Studies have suggested that people with MS who have lower vitamin D levels have more attacks of MS. It is not known if giving extra vitamin D to people with MS helps make the disease better or not.

Some doctors of people with MS give them vitamin D already, although they don’t know if it is helpful or not. The Institute of Medicine recommends that every person take 600 international units (IU) of vitamin D each day. The study doctors want to know if giving a higher dose of vitamin D, 5,000 IU each day can help lower the risk of MS attacks or MS worsening.

All participants will receive an approved treatment for MS called glatiramer acetate (Copaxone). Half of the people will receive standard-dose vitamin D (600 IU), and half will receive high-dose vitamin D (5,000 IU).

Participation in this study will last for two years.

If you have been diagnosed with a relapsing form of MS, are between the ages of 18-50 and are able to come to UCSF for study visits you may be eligible to participate.

For more information, please contact Nisha Raj Revirajan at .(JavaScript must be enabled to view this email address) with ‘"Vitamin D RCT"’ in the subject line or at (415) 502 7220.

Vitamin D Pilot Study - Pharmacodynamic and Immunologic Effects of Vitamin D Supplementation in Patients with multiple sclerosis and Healthy Controls

The purpose of this study is to determine if patients with multiple sclerosis (MS) who are given vitamin D3 supplements have differences in the way their bodies process vitamin D or the way their immune system is affected by vitamin D than those who are healthy. Specifically, we will see if giving patients with MS and healthy people the same dose of vitamin D3 leads to the same increase in the blood concentration of vitamin D. We will also study what happens to the immune system and to the change in how specific genes are controlled when people with MS and healthy people are given vitamin D. The study will also be helpful because it will tell the study doctors if the dose they are using in this study is an appropriate dose for a larger future study that will determine if giving vitamin D to patients with MS helps make the disease better.

Participation is this study will last for about 90 days (three months) and will include four visits, each taking about one hour.

Closed to enrollment.